Effects of Caffeine on Intervertebral Disc Cell Viability in a Whole Organ Culture Model.

Benjamin T RainesJames T StannardOlivia E StricklinAaron M StokerTheodore J ChomaJames L Cook

Published in: Global spine journal (2020)

Caffeine intake may be a risk factor for IVD degeneration, especially in conjunction with disc injury. Mechanisms for caffeine associated disc degeneration may involve cell and ECM, and further studies should elucidate mechanistic pathways and potential benefits for caffeine restriction.

Keyphrases

single cell
cell therapy
stem cells
body mass index
risk assessment
mesenchymal stem cells
case control