Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration.

Sudeshna DasZhaozhi LiAyush NooriBradley T HymanAlberto Serrano-Pozo

Published in: Journal of neuroinflammation (2020)

Acute and chronic CNS injuries lead to distinct astrocyte gene expression programs beyond their common astrocyte reaction signature. However, caution should be taken when extrapolating astrocyte transcriptomic findings from mouse models to human diseases.

Keyphrases

gene expression
liver failure
systematic review
respiratory failure
drug induced
single cell
endothelial cells
blood brain barrier
case control
aortic dissection
mouse model
rna seq
dna methylation
hepatitis b virus
intensive care unit
acute respiratory distress syndrome
electron transfer