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Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration.

Sudeshna DasZhaozhi LiAyush NooriBradley T HymanAlberto Serrano-Pozo
Published in: Journal of neuroinflammation (2020)
Acute and chronic CNS injuries lead to distinct astrocyte gene expression programs beyond their common astrocyte reaction signature. However, caution should be taken when extrapolating astrocyte transcriptomic findings from mouse models to human diseases.
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