Oral delivery of brain-targeted miltefosine-loaded alginate nanoparticles functionalized with polysorbate 80 for the treatment of cryptococcal meningitis.

Cristina C SpadariDylan M LanserMarcelo V AraújoDaniel F F De JesusLuciana B LopesAngie GelliKelly Ishida

Published in: The Journal of antimicrobial chemotherapy (2023)

These results support the potential use of P80-functionalized alginate nanoparticles as miltefosine carriers for non-toxic and effective alternative oral treatment, enabling BBB translocation and reduction of fungal infection in the brain.

Keyphrases

white matter
drug delivery
resting state
cancer therapy
multiple sclerosis
mass spectrometry
high resolution
tissue engineering
tandem mass spectrometry