Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COVID-19.

Jingqi Zhou Yitang Sun Weishan Huang Kaixiong Ye

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2021)

Our findings suggest that altered blood cell traits, especially those of monocyte, eosinophil, and neutrophil, may represent the mechanistic links between the genetic locus 3p21.31 and severe COVID-19. They may also underlie the increased risk of severe COVID-19 in older adults and men.

Keyphrases

coronavirus disease
sars cov
genome wide
single cell
early onset
cell therapy
physical activity
respiratory syndrome coronavirus
dna methylation
dendritic cells
drug induced
endothelial cells
immune response
stem cells
gene expression
middle aged
genome wide association study
peripheral blood