Identification of three capsule depolymerases in a bacteriophage infecting Klebsiella pneumoniae capsular types K7, K20, and K27 and therapeutic application.

Jia-Wen WuJin-Town WangTzu-Lung LinYa-Zhu LiuLii-Tzu WuJin-Town Wang

Published in: Journal of biomedical science (2023)

The potential of capsule depolymerase K20dep for the treatment of K. pneumoniae infections was revealed using an in vivo infection model. In addition, K7dep, K20dep, and K27dep capsule depolymerases could be used for K. pneumoniae capsular typing.

Keyphrases

klebsiella pneumoniae
multidrug resistant
escherichia coli
single cell
respiratory tract
bioinformatics analysis