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Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease.

Bryan R ConwayEoin Daniel O'SullivanCarolynn CairnsJames O'SullivanDaniel J SimpsonAngela SalzanoKatie ConnorPeng DingDuncan HumphriesKevin StewartOliver TeenanRiinu PiusNeil C HendersonCécile BénézechPrakash RamachandranDavid A FerenbachJeremy HughesTamir ChandraLaura Denby
Published in: Journal of the American Society of Nephrology : JASN (2020)
Complementary technologies identified novel myeloid subtypes, based on transcriptomics in single cells, that represent therapeutic targets to inhibit progression or promote regression of kidney disease.
Keyphrases
  • single cell
  • rna seq
  • induced apoptosis
  • bone marrow
  • dendritic cells
  • high throughput
  • acute myeloid leukemia
  • cell cycle arrest
  • immune response
  • oxidative stress
  • cell death
  • pi k akt