Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation.
Claire A SheaRebecca A RolfeHelen McNeillPaula MurphyPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2019)
These findings implicate YAP signalling, independent of Fat4, in the transduction of mechanical signals during key stages of skeletal patterning in the developing limb, in particular endochondral ossification and shape emergence, as well as patterning of tissues at the developing synovial joint.