In utero exposure to ultrafine particles promotes placental stress-induced programming of renin-angiotensin system-related elements in the offspring results in altered blood pressure in adult mice.
Russell A Morales-RubioIsabel Alvarado-CruzNatalia Manzano-LeónMaria-de-Los-Angeles Andrade-OlivaMarisela Uribe-RamirezBetzabet Quintanilla-VegaÁlvaro Osornio-VargasAndrea De Vizcaya-RuizPublished in: Particle and fibre toxicology (2019)
In utero UFP exposure promotes placental stress through inflammation and oxidative stress, and programs RAS-related elements that result in altered blood pressure in the offspring. Exposure to UFP during fetal development could influence susceptibility to CVD in adulthood.
Keyphrases
- stress induced
- blood pressure
- oxidative stress
- high fat diet
- hypertensive patients
- heart rate
- depressive symptoms
- public health
- dna damage
- metabolic syndrome
- ischemia reperfusion injury
- diabetic rats
- signaling pathway
- adipose tissue
- blood glucose
- young adults
- particulate matter
- high fat diet induced
- insulin resistance
- endoplasmic reticulum stress