Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos.

Takuma ShinozukaMotoko AokiYudai HatakeyamaNoriaki SasaiHiroshi OkamotoShinji Takada

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2023)

Our results show that Rspo1 and Rspo3 are dispensable for most developmental processes involving roof plate-derived Wnt ligands, except for specification of a subtype of neural crest cells. Thus, Rspos may modulate Wnt/β-catenin signaling in a context-dependent manner.

Keyphrases

stem cells
cell proliferation
induced apoptosis
cell cycle arrest
cell fate
single cell
pi k akt