Effective action of silymarin against ketamine-induced schizophrenia in male mice: Insight into the biochemical and molecular mechanisms of action.

Benneth Ben-AzuAliance R FokouaOlajide S AnnafiOlusegun G AdebayoElisabetta C Del ReNneka OkuchukwuGbemileke J AregbesolaAkpor-Esiri C EjenaviDavid M IsiweleArausi J EfezinoIfelunwa D Okpu

Published in: Journal of psychiatric research (2024)

Overall, these findings suggest that silymarin's antipsychotic effect might be primarily associated, among other mechanisms, with the normalization of neurochemical and neurotrophic changes in the mice brains.

Keyphrases

bipolar disorder
high glucose
diabetic rats
high fat diet induced
pain management
drug induced
oxidative stress
adipose tissue
chronic pain