Supramolecular subphthalocyanine complexes-cellular uptake and phototoxicity.

Justin DubbertAlexander HöingNathalie RiekShirley K Knauer Jens Voskuhl

Published in: Chemical communications (Cambridge, England) (2021)

In this communication we report on the synthesis and application of axially functionalized boron-subphthalocyanines (SubPC) which are able to form host-guest complexes with cyclodextrins. Here, a tert-butylphenyl substituted SubPC was investigated concerning its complexation with β-cyclodextrin (β-CD) and a β-cyclodextrin polymer. NMR-titrations showed the formation of a 1 : 1 complex with β-CD. These assemblies were analyzed for their cellular distribution as well as their phototoxicity towards HeLa cells.

Keyphrases

cell cycle arrest
capillary electrophoresis
induced apoptosis
magnetic resonance
cell death
nk cells
high resolution
molecular docking
water soluble
quantum dots
endoplasmic reticulum stress
signaling pathway
cell proliferation
molecular dynamics simulations
solid phase extraction