Serum phosphorus as a driver of skeletal morbidity in fibrous dysplasia.

Zubeyir Hasan GunCharles OsamorJocelyn TaylorXiaobai LiVivian SzymczukAlison M Boyce

Published in: The Journal of clinical endocrinology and metabolism (2023)

Both frank hypophosphatemia and low-normophosphatemia are associated with increased FD-related complications. This supports FGF23-mediated hypophosphatemia as a driver of skeletal morbidity, which may impact a larger proportion of the FD/MAS population than previously recognized. These findings will allow clinicians to identify at-risk patients, and will inform the development of prospective studies to determine optimal therapeutic targets.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
risk factors
drug induced
sewage sludge