Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia.
Tingting HeWanlu LiYaying SongZongwei LiYaohui TangZhijun ZhangYongting WangPublished in: Journal of neuroinflammation (2020)
Sestrin2 exhibited neuroprotection by shifting microglia polarization from the M1 to M2 phenotype in ischemic mouse brain, which may be due to suppression of the mTOR signaling pathway and the restoration of autophagic flux.
Keyphrases
- cell death
- cerebral ischemia
- signaling pathway
- inflammatory response
- cell proliferation
- neuropathic pain
- oxidative stress
- pi k akt
- brain injury
- subarachnoid hemorrhage
- resting state
- white matter
- blood brain barrier
- epithelial mesenchymal transition
- ischemia reperfusion injury
- induced apoptosis
- functional connectivity
- spinal cord injury
- endoplasmic reticulum stress