ALS is a multistep process in South Korean, Japanese, and Australian patients.

Steve VucicMana HigashiharaGen SobueNaoki AtsutaYuriko DoiSatoshi KuwabaraSeung Hyun KimInah KimKi-Wook OhJinseok ParkEun Mi KimPaul TalmanParvathi MenonMatthew C Kiernannull null

Published in: Neurology (2020)

The linear relationship between log age and log incidence is consistent with a multistage model of disease, with slope estimated suggesting that 6 steps were required in Japanese and Australian patients with ALS while 5 steps were needed in South Korean patients. Identification of these steps could identify novel therapeutic strategies.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
risk factors
neural network