Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease.
Farhan KhanZiyad AllehebiYahya ShabiIan DavisJason LeBlancRobbin LindsayTodd F HatchettePublished in: Open forum infectious diseases (2022)
The modified 2-tier testing algorithm (MTTT) for Lyme disease (LD) has been approved by the US Food and Drug Administration. In this study, we show that the MTTT detected 28% more cases of early infection compared with the standard 2-tier algorithm while retaining high specificity in a region with a high incidence of LD.