Prostate Cancer Transcriptomic Regulation by the Interplay of Germline Risk Alleles, Somatic Mutations, and 3D Genomic Architecture.

Jiapei Yuan Kathleen E Houlahan Susmita G Ramanand Sora Lee GuemHee Baek Yang Yang Yong Chen Douglas W Strand Michael Q Zhang Paul C Boutros Ram S Mani

Published in: Cancer discovery (2022)

Many prostate cancer germline risk alleles are enriched in the noncoding regions of the genome and are hypothesized to regulate transcription. We present a 3D genomics framework to unravel risk SNP function and describe the widespread germline-somatic interplay in transcription control. This article is highlighted in the In This Issue feature, p. 2711.

Keyphrases

prostate cancer
radical prostatectomy
dna repair
copy number
genome wide
transcription factor
machine learning
dna methylation
deep learning