New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities.
Lin-Lin JiXin WangJin-Jie LiXiang-Jian ZhongBo ZhangJing JuanXiao-Ya ShangPublished in: Molecules (Basel, Switzerland) (2019)
Three previously undescribed iridoids, cornusfurals A⁻C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.
Keyphrases
- magnetic resonance
- mass spectrometry
- high resolution
- high glucose
- diabetic rats
- oxidative stress
- cerebral ischemia
- single cell
- molecular docking
- cell therapy
- drug induced
- endothelial cells
- magnetic resonance imaging
- cell proliferation
- signaling pathway
- mesenchymal stem cells
- ms ms
- bone marrow
- essential oil
- contrast enhanced
- pi k akt