Type 2 diabetes mellitus promotes the proliferation, metastasis, and suppresses the apoptosis in oral squamous cell carcinoma.
Xin HuJin WuHaofeng XiongLiujun ZengZijia WangCan WangDanni HuangTianyi ZhangYing PengWeijun ChenKun XiaTong SuPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2021)
Our results implicated that type 2 diabetes mellitus may play a crucial role in the development and progression of oral squamous cell carcinoma through hyperglycemia, affecting cancer cell proliferation, migration, and apoptosis. This finding might provide a new direction for the prevention and treatment of oral squamous cell carcinoma.
Keyphrases
- cell proliferation
- cell cycle arrest
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- cell death
- glycemic control
- pi k akt
- papillary thyroid
- cardiovascular risk factors
- squamous cell
- type diabetes
- diabetic rats
- squamous cell carcinoma
- combination therapy
- metabolic syndrome
- adipose tissue
- young adults
- smoking cessation
- replacement therapy