Role of Lgals9 Deficiency in Attenuating Nephritis and Arthritis in BALB/c Mice in a Pristane-Induced Lupus Model.

Sonia ZeggarKatsue S WatanabeSanae TeshigawaraSumie HiramatsuTakayuki KatsuyamaEri KatsuyamaHaruki WatanabeYoshinori MatsumotoTomoko KawabataKen-Ei SadaToshiro NikiMitsuomi HirashimaJun Wada

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2018)

Gal-9 is required for the induction and development of lupus nephritis and arthritis in this murine model of SLE. The results of the current investigation provide a potential new strategy in which antagonism of Gal-9 may be beneficial for the treatment of nephritis and arthritis in patients with SLE through targeting of activated macrophages.

Keyphrases

systemic lupus erythematosus
rheumatoid arthritis
disease activity
high glucose
replacement therapy
cancer therapy
diabetic rats
type diabetes
risk assessment
drug induced
combination therapy
oxidative stress
drug delivery
human health
insulin resistance
wild type