Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients.
Helena OliveresDavid PesántezJoan MaurelPublished in: International journal of molecular sciences (2021)
Insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation. Upregulation of the IGF1R pathway constitutes a common paradigm shared with other receptor tyrosine kinases such as EGFR, HER2, and MET in different cancer types, including colon cancer. The main IGF1R signaling pathways are PI3K-AKT and MAPK-MEK. However, different processes, such as post-translational modification (SUMOylation), epithelial-to-mesenchymal transition (EMT), and microenvironment complexity, can also contribute to intrinsic and acquired resistance. Here, we discuss new strategies for adequate drug development in metastatic colorectal cancer patients.
Keyphrases
- pi k akt
- signaling pathway
- tyrosine kinase
- cell proliferation
- cell cycle arrest
- epidermal growth factor receptor
- epithelial mesenchymal transition
- metastatic colorectal cancer
- small cell lung cancer
- induced apoptosis
- end stage renal disease
- ejection fraction
- stem cells
- newly diagnosed
- binding protein
- prognostic factors
- growth hormone
- peritoneal dialysis
- oxidative stress
- patient reported