Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review.
Rossella TozziFiammetta CiprianiDavide MasiSabrina BascianiMikiko WatanabeCarla LubranoLucio GnessiStefania MarianiPublished in: Nutrients (2022)
Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past two decades given their pivotal function in a variety of biological contexts, including transcriptional regulation, cell cycle progression, inflammation, metabolism, neurological and cardiovascular physiology, and cancer. As a consequence, the modulation of KBs and SIRT1 is considered a promising therapeutic option for many diseases. The direct regulation of gene expression can occur in vivo through histone modifications mediated by both SIRT1 and KBs during fasting or low-carbohydrate diets, and dietary metabolites may contribute to epigenetic regulation, leading to greater genomic plasticity. In this review, we provide an updated overview of the epigenetic interactions between KBs and SIRT1, with a particular glance at their central, synergistic roles for metabolic health.
Keyphrases
- gene expression
- oxidative stress
- cell cycle
- dna methylation
- ischemia reperfusion injury
- healthcare
- public health
- cell proliferation
- mental health
- health information
- ms ms
- working memory
- squamous cell carcinoma
- transcription factor
- insulin resistance
- metabolic syndrome
- cancer therapy
- social media
- blood pressure
- climate change
- health promotion
- adipose tissue
- blood brain barrier
- young adults
- skeletal muscle
- human health