Stemness, Inflammation and Epithelial-Mesenchymal Transition in Colorectal Carcinoma: The Intricate Network.
Inese BriedeDainis BalodisJanis GardovskisIlze StrumfaPublished in: International journal of molecular sciences (2021)
In global cancer statistics, colorectal carcinoma (CRC) ranks third by incidence and second by mortality, causing 10.0% of new cancer cases and 9.4% of oncological deaths worldwide. Despite the development of screening programs and preventive measures, there are still high numbers of advanced cases. Multiple problems compromise the treatment of metastatic colorectal cancer, one of these being cancer stem cells-a minor fraction of pluripotent, self-renewing malignant cells capable of maintaining steady, low proliferation and exhibiting an intriguing arsenal of treatment resistance mechanisms. Currently, there is an increasing body of evidence for intricate associations between inflammation, epithelial-mesenchymal transition and cancer stem cells. In this review, we focus on inflammation and its role in CRC stemness development through epithelial-mesenchymal transition.
Keyphrases
- epithelial mesenchymal transition
- cancer stem cells
- signaling pathway
- transforming growth factor
- oxidative stress
- papillary thyroid
- induced apoptosis
- metastatic colorectal cancer
- stem cells
- risk factors
- squamous cell
- public health
- cell death
- cardiovascular disease
- combination therapy
- pi k akt
- endoplasmic reticulum stress
- prostate cancer
- lymph node metastasis
- cell proliferation