Liver enzyme elevation in patients taking HAART compared with treatment naïve controls at Debre Berhan Referral Hospital: a comparative cross-sectional study, Northeast Ethiopia.
Endalamaw TesfaDaniel SiefuYididya BelaynehZewdie MekonnenPublished in: BMC research notes (2019)
A total of 152 individuals (76 cases and 76 controls) were included in this study. The mean ages of treatment and control groups were 37.37 and 36.38 respectively. The mean values of liver enzymes (ALT, AST and ALP), total bilirubin and direct bilirubin were significantly higher (p < 0.05) while, total protein and creatinine were significantly lower in patients taking HAART compared with treatment naïve controls. In this study, about 19 (25%) of clients in HAART treated groups and 7 (9.2%) of treatment naïve controls had showed liver enzyme changes. Moreover, 23.7% and 1.3% of the HAART treated groups developed mild and moderate liver enzyme elevation or hepatotoxicity, respectively. In this study, significant difference was observed in liver enzyme elevation between ART and pre-ART patients. As a result, regular clinical and laboratory monitoring of liver function will be necessary to prevent severe form of liver injury.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- liver injury
- chronic kidney disease
- drug induced
- peritoneal dialysis
- healthcare
- prognostic factors
- metabolic syndrome
- hiv infected
- combination therapy
- hiv infected patients
- small molecule
- replacement therapy
- antiretroviral therapy
- patient reported outcomes
- protein protein
- amino acid
- acute care