Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts.

Neha A SatheLeila R ZelnickCarmen MikacenicEric D MorrellPavan K BhatrajuJ Brennan McNeilSusanna KosamoCatherine L HoughW Conrad LilesLorraine B WareMark M Wurfel

Published in: Critical care (London, England) (2021)

Patients with persistent HRF are common and have higher mortality and elevated circulating markers of lung injury compared to resolving HRF, and yet only a subset are captured by ARDS definitions. Persistent HRF may represent a clinically important, inclusive target for future therapeutic trials in HRF.

Keyphrases

respiratory failure
extracorporeal membrane oxygenation
mechanical ventilation
acute respiratory distress syndrome
intensive care unit
cardiovascular events
current status
liver failure
coronary artery disease