AMPK Drives Both Glycolytic and Oxidative Metabolism in T Cells During Graft-versus-host Disease.
Archana RamgopalErica L BravermanLee-Kai SunDarlene MonlishChristopher WittmannManda J RamseyRichard CaitleyWilliam HawseCraig A ByersdorferPublished in: bioRxiv : the preprint server for biology (2023)
AMPK plays a key role in driving both and oxidative and glycolytic metabolism in T cells during graft-versus-host disease (GVHD)Absence of AMPK simultaneously impairs both glycolytic enzyme activity, most notably by aldolase, and interferon gamma (IFNγ) production.