Integrated Analysis of Ovarian Juvenile Granulosa Cell Tumors Reveals Distinct Epigenetic Signatures and Recurrent TERT Rearrangements.

Theodore VougiouklakisKelsey ZhuVarshini VasudevarajaJonathan SerranoGuomiao ShenRebecca L LinnXiaojun FengSarah ChiangJulieta E BarroetaKristen M ThomasLauren E SchwartzPratibha Sharma ShuklaAnais MalpicaEsther OlivaPaolo CotziaDeborah F DeLairMatija SnuderlGeorge Jour

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

This is the largest comprehensive molecular study of JGCTs, where we further expand our current understanding of JGCT pathogenesis and demonstrate putative oncogenic drivers and TERT rearrangements in a subset of tumors. Our findings further offer insights into possible targeted therapies in a rare entity.

Keyphrases

dna methylation
single cell
gene expression
transcription factor
genome wide
metabolic syndrome
bone marrow
insulin resistance