Palladium-Catalyzed Asymmetric Decarboxylative Addition of β-Keto Acids to Heteroatom-Substituted Allenes.

The Pd-catalyzed asymmetric addition reaction of β-keto acids to heteroatom-substituted allene is reported. This reaction generates β-substituted ketones in an asymmetric manner through a branch-selective decarboxylative allylation pathway. The reaction accommodates various alkoxyallenes as well as amidoallenes.