Single-cell RNA sequencing of cystic fibrosis liver disease explants reveals endothelial complement activation.
Mathias DeclercqLucas TrepsVincent GeldhofNadine V ConchinhaLaura P M H de RooijAbhishek SubramanianMagalie FeyeuxMarine CotinatBram BoeckxStefan VinckierLieven DupontFrancois VermeulenMieke BoonMarijke ProesmansLouis LibbrechtJacques PirenneDiethard MonbaliuIna JochmansMieke DewerchinGuy EelenTania A RoskamsStijn VerledenDiether LambrechtsPeter CarmelietPeter WittersPublished in: Liver international : official journal of the International Association for the Study of the Liver (2024)
Our work showed novel aspects of human liver ECs at the single-cell level thereby supporting endothelial involvement in CFLD, and reinforcing the hypothesis that ECs could be a driver of PSVD. Therefore, considering the vascular compartment in CF and CFLD may help developing new therapeutic approaches for these diseases.