Renal disorders are an emerging global public health issue with a higher growth rate despite progress in supportive therapies. In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. The self-renewal and proliferative nature of stem cells raised the hope to fight against various diseases. Similarly, it opens a new path for the treatment and repair of damaged renal cells. This review focuses on the types of renal diseases; acute and chronic kidney disease-their statistical data, and the conventional drugs used for treatment. It includes the possible stem cell therapy mechanisms involved and outcomes recorded so far, the limitations of using these regenerative medicines, and the progressive improvement in stem cell therapy by adopting approaches like PiggyBac, Sleeping Beauty, and the Sendai virus. Specifically, about the paracrine activities of amniotic fluid stem cells, renal stem cells, embryonic stem cells, mesenchymal stem cell, induced pluripotent stem cells as well as other stem cells.
Keyphrases
- stem cells
- cell therapy
- public health
- mesenchymal stem cells
- chronic kidney disease
- multiple sclerosis
- bone marrow
- induced apoptosis
- combination therapy
- liver failure
- end stage renal disease
- cell proliferation
- adipose tissue
- extracorporeal membrane oxygenation
- endoplasmic reticulum stress
- mechanical ventilation
- peritoneal dialysis
- oxidative stress