Albuterol-Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma.

Alberto PapiBradley E ChippsRichard BeasleyReynold A PanettieriElliot IsraelMark CooperLynn DunsireAllison Jeynes-EllisEva JohnssonRobert ReesChristy CappellettiFrank C Albers

Published in: The New England journal of medicine (2022)

The risk of severe asthma exacerbation was significantly lower with as-needed use of a fixed-dose combination of 180 μg of albuterol and 160 μg of budesonide than with as-needed use of albuterol alone among patients with uncontrolled moderate-to-severe asthma who were receiving a wide range of inhaled glucocorticoid-containing maintenance therapies. (Funded by Avillion; MANDALA ClinicalTrials.gov number, NCT03769090.).

Keyphrases

chronic obstructive pulmonary disease
lung function
cystic fibrosis
high intensity
extracorporeal membrane oxygenation
respiratory failure