Interferon-gamma contributes to disease progression in the Ndufs4(-/-) model of Leigh syndrome.
Allison R HanafordAsheema KhannaKaterina JamesVivian TruongRyan LiaoYihan ChenMichael MulhollandErnst-Bernhard KayserKino WatanabeErin Shien HsiehMargaret SedenskyPhilip G MorganVandana KaliaSurojit SarkarAllison R HanafordPublished in: Neuropathology and applied neurobiology (2024)
IFNγ contributes to disease onset and progression in LS. Our findings suggest that IFNγ targeting therapies may provide some benefits in genetic mitochondrial disease, but targeting IFNγ alone would likely yield only modest benefits in LS.