Neuropsychiatric symptoms and striatal monoamine availability in early Parkinson's disease without dementia.

Yoon-Sang OhJean Hee KimSang-Won YooEo-Jin HwangChul Hyoung LyooKwang-Soo LeeJoong Seok Kim

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)

Patients with early PD who have neuropsychiatric symptoms had a lower monoamine availability in the thalamus than those with no neuropsychiatric symptoms. This finding suggests that decreased monoamine transporter availability in the thalamus may be an imaging biomarker of neuropsychiatric symptoms in patients with PD.

Keyphrases

sleep quality
high resolution
deep brain stimulation
mild cognitive impairment
mass spectrometry
depressive symptoms
photodynamic therapy