Are apoptosis-determining techniques useful to establish an early diagnosis of acute graft-vs-host disease in pediatric patients under treatment with multiple drugs?

Edna Morán-VillaseñorCecilia Serrano-PachecoLuz Orozco-CovarrubiasChiharu MurataRodolfo Rodríguez-JuradoAlberto Olaya-VargasMarimar Saez-de-Ocariz

Published in: Journal of cutaneous pathology (2020)

The presence of ≥4 apoptotic keratinocytes per 10 hpf (in aGVHD) and the absence of follicular apoptotic cells (in SDRs) might be a useful marker to distinguish between them.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
endoplasmic reticulum stress
liver failure
oxidative stress
drug induced
anti inflammatory
pi k akt
respiratory failure
signaling pathway
intensive care unit
combination therapy