Intraductal/ductal histology and lymphovascular invasion are associated with germline DNA-repair gene mutations in prostate cancer.
Pedro Isaacsson VelhoJohn L SilbersteinMark C MarkowskiJun LuoTamara L LotanWilliam B IsaacsEmmanuel S AntonarakisPublished in: The Prostate (2018)
Presence of intraductal/ductal histology and lymphovascular invasion appear to be associated with pathogenic germline DNA-repair gene mutations in men with prostate cancer, and identification of these features may help to select patients for germline testing. NCCN guidelines may be inadequate in predicting which prostate cancer patients should undergo genetic screening.
Keyphrases
- dna repair
- prostate cancer
- dna damage
- radical prostatectomy
- dna damage response
- end stage renal disease
- chronic kidney disease
- cell migration
- ejection fraction
- newly diagnosed
- lymph node metastasis
- endometrial cancer
- peritoneal dialysis
- prognostic factors
- oxidative stress
- squamous cell carcinoma
- clinical practice
- patient reported outcomes
- middle aged