A recombinant rabies virus chimera expressing the DC-targeting molecular MAB2560 shows enhanced vaccine immunogenicity through activation of dendritic cells.
Zhiyuan GongPei HuangHongli JinYujie BaiHailun LiMeichen QianJingxuan SunCuicui JiaoMengyao ZhangYuanyuan LiHaili ZhangHualei WangPublished in: PLoS neglected tropical diseases (2023)
In summary, the recombinant virus rCVS11-MAB2560 chimeric-expressing the molecular adjuvant MAB2560 can stimulate high levels of humoral and cellular immune responses in vivo and can be used as an effective inactivated rabies vaccine candidate.