Mesenchymal stem cell-derived extracellular vesicles as probable triggers of radiation-induced heart disease.

Lan LuoChen YanNaoki FuchiYukinobu KodamaXu ZhangGoto ShinjiKiyonori MiuraHitoshi SasakiTao-Sheng Li

Published in: Stem cell research & therapy (2021)

EVs released from irradiated MSCs show altered miRNA profiles and harmful effects on heart cells, which provides new insight into the mechanism of radiation-related heart disease risks.

Keyphrases

radiation induced
mesenchymal stem cells
radiation therapy
pulmonary hypertension
induced apoptosis
umbilical cord
cell cycle arrest
heart failure
bone marrow
human health
atrial fibrillation
cell therapy
risk assessment
signaling pathway
cell death
cell proliferation
climate change