Login / Signup

The genomics of major psychiatric disorders in a large pedigree from Northern Sweden.

Jin SzatkiewiczJames J CrowleyAnnelie Nordin AdolfssonKarolina A ÅbergMaaike AlaertsGiulio GenoveseSteven McCarrollJurgen Del-FaveroRolf AdolfssonPatrick F Sullivan
Published in: Translational psychiatry (2019)
We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.
Keyphrases
  • genome wide
  • bipolar disorder
  • copy number
  • dna methylation
  • major depressive disorder
  • healthcare
  • mental health
  • single cell
  • high density
  • gene expression
  • gestational age
  • preterm birth