DHX15 is up-regulated in castration-resistant prostate cancer and required for androgen receptor sensitivity to low DHT concentrations.

Yadong XuQiong SongLaura E PascalMingming ZhongYibin ZhouJianhua ZhouFang-Ming DengJiaoti HuangZhou Wang

Published in: The Prostate (2019)

These findings suggest that DHX15 contributes to prostate cancer progression. DHX15 is required for androgen receptor sensitivity to low DHT concentrations and contributes to enzalutamide resistance in C4-2 cells. Targeting DHX15 may improve the ADT treatment.

Keyphrases

prostate cancer
radical prostatectomy
induced apoptosis
cell cycle arrest
transcription factor
cancer therapy
oxidative stress
endoplasmic reticulum stress
cell proliferation
smoking cessation