Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors.
Pelin Balcik-ErcinMetin CetinIrem Yalim-CamciGorkem OdabasNurettin TokayA Emre SayanTamer YagciPublished in: Cellular oncology (Dordrecht) (2018)
Our observation that ZEB2 negatively regulates a GalNAc-transferase (GALNT3) that is involved in O-glycosylation adds another layer of complexity to the role of ZEB2 in cancer progression and metastasis. Proteins glycosylated by GALNT3 may be exploited as novel diagnostics and/or therapeutic targets.