IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity.

Zengbin WangPei SunBanglun PanJiacheng QiuXiaoxia ZhangShuling ShenXiaoling KeNanhong Tang

Published in: Cell communication and signaling : CCS (2023)

These results shed insight on the potential of inhibiting cGAS/STING as a therapy for AILI and emphasize the crucial role of IL-33/ST2 signaling in the regulation of APAP-induced STING signaling. Video Abstract.

Keyphrases

signaling pathway
cell death
oxidative stress
high glucose
diabetic rats
liver injury
risk assessment