The Covalent CDK7 Inhibitor THZ1 Potently Induces Apoptosis in Multiple Myeloma Cells In Vitro and In Vivo.

Yu ZhangLiang ZhouDipankar BandyopadhyayKanika SharmaAlexander Joseph AllenMaciej KmieciakSteven Grant

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

THZ1 potently reduces multiple myeloma cell proliferation through transcriptional downregulation of MCL-1, BCL-XL, and c-MYC in vitro and in vivo. It warrants further attention as a therapeutic agent in multiple myeloma.

Keyphrases

multiple myeloma
cell proliferation
cell cycle
induced apoptosis
signaling pathway
cell cycle arrest
gene expression
working memory
transcription factor
oxidative stress