Durable remission for four pediatric patients with high-risk relapsed classical Hodgkin lymphoma treated with brentuximab vedotin plus gemcitabine but without autologous stem cell transplantation: A report from the Children's Oncology Group.
Ilia N BuhtoiarovNkechi I MbaCrystal D L SantosKathleen M McCartenMonika L MetzgerQinglin PeiRizvan BushKayla BakerKara M KellyPeter D ColePublished in: Pediatric blood & cancer (2022)
Patients with therapy-refractory or high-risk relapsed classical Hodgkin lymphoma are typically treated with the high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) to consolidate the response to salvage therapy. The combination of brentuximab vedotin with gemcitabine has recently been shown to be an effective and safe salvage regimen. While the majority of patients with complete responses to this regimen ultimately underwent HDC/ASCT consolidation, four subjects, reported herein, achieved durable complete remissions lasting more than 4 years after the study treatment but without ASCT consolidation. Further investigation of treatment strategies incorporating targeted agents may allow omission of HDC/ASCT for select patients.
Keyphrases
- hodgkin lymphoma
- stem cell transplantation
- high dose
- low dose
- newly diagnosed
- end stage renal disease
- locally advanced
- cell therapy
- bone marrow
- ejection fraction
- chronic kidney disease
- prognostic factors
- young adults
- palliative care
- peritoneal dialysis
- squamous cell carcinoma
- platelet rich plasma
- acute lymphoblastic leukemia
- radiation therapy
- rheumatoid arthritis
- disease activity
- stem cells
- diffuse large b cell lymphoma
- multiple myeloma