Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye.

Pavlos MsaouelCheryl L WalkerGiannicola GenoveseNizar M Tannir

Published in: Molecular & cellular oncology (2020)

Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress as a targetable vulnerability for this disease.

Keyphrases

gene expression
climate change
single molecule
transcription factor
heat stress