Young bone marrow transplantation prevents aging-related muscle atrophy in a senescence-accelerated mouse prone 10 model.

Aiko InoueLimei PiaoXueling YueZhe HuangLina HuHongxian WuXiangkun MengWenhu XuChenglin YuTakeshi SasakiKohji ItakuraHiroyuki UmegakiMasafumi KuzuyaXian Wu Cheng

Published in: Journal of cachexia, sarcopenia and muscle (2022)

These findings suggest that YBMT can prevent muscle wasting and dysfunction by mitigating apoptosis and proliferation via a modulation of GDF-11 signalling and mitochondrial dysfunction in SAMP10 mice.

Keyphrases

bone marrow
oxidative stress
skeletal muscle
mesenchymal stem cells
signaling pathway
dna damage
cell cycle arrest
endothelial cells
cell death
type diabetes
adipose tissue
pi k akt
drug induced
wild type