Persistent post-COVID-19 neuromuscular symptoms.
Rory M C AbramsLan ZhouSusan C ShinPublished in: Muscle & nerve (2023)
Neuromuscular symptoms may develop or persist after resolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Besides residual sensorimotor symptoms associated with acute neuromuscular complications of coronavirus disease-2019 (COVID-19), such as Guillain-Barré syndrome, critical illness neuromyopathy, and rhabdomyolysis, patients may report persistent autonomic symptoms, sensory symptoms, and muscle symptoms in the absence of these acute complications, including palpitations, orthostatic dizziness and intolerance, paresthesia, myalgia, and fatigue. These symptoms may be associated with long COVID, also known as post-COVID-19 conditions or postacute sequelae of SARS-CoV-2 infection, which may significantly impact quality of life. Managing these symptoms represents a challenge for health-care providers. Recent advances have identified small-fiber neuropathy as a potential etiology that may underlie autonomic dysfunction and paresthesia in some long COVID patients. The pathogenic mechanisms underlying myalgia and fatigue remain elusive and need to be investigated. Herein we review the current state of knowledge regarding the evaluation and management of patients with persistent post-COVID-19 neuromuscular symptoms.
Keyphrases
- coronavirus disease
- respiratory syndrome coronavirus
- sars cov
- sleep quality
- healthcare
- oxidative stress
- liver failure
- end stage renal disease
- newly diagnosed
- case report
- skeletal muscle
- acute kidney injury
- intensive care unit
- climate change
- single molecule
- peritoneal dialysis
- physical activity
- high resolution
- risk assessment
- respiratory failure
- social media
- drug induced
- acute respiratory distress syndrome
- aortic dissection