Maternal zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1α pathway.
Liang HuangWei GaoXuri HeTong YuanHuaqi ZhangXiufen ZhangWenxuan ZhengQilin WuJu LiuWence WangLin YangYongwen ZhuPublished in: Journal of animal science and biotechnology (2023)
The present study provides a new way to protect offspring against oxidative damage by maternal Zn supplementation through the process of targeting mitochondria involving the activation of Nrf2/PGC-1α signaling.
Keyphrases
- oxidative stress
- diabetic rats
- skeletal muscle
- birth weight
- induced apoptosis
- dna damage
- pregnancy outcomes
- ischemia reperfusion injury
- cell death
- high glucose
- high fat diet
- heavy metals
- pregnant women
- body mass index
- mouse model
- drug delivery
- type diabetes
- risk assessment
- drug induced
- gestational age
- weight loss
- heat shock
- endothelial cells
- endoplasmic reticulum
- endoplasmic reticulum stress
- stress induced
- heat stress