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The Impact of the Genetic Polymorphism in DNA Repair Pathways on Increased Risk of Glioblastoma Multiforme in the Arab Jordanian Population: A Case-Control Study.

Sohaib M Al-KhatibNour AbdoLaith Naser Al-EitanAbdel-Hameed W Al-MistarehiDeeb Jamil ZahranMarwan Al AjlouniTariq Zuheir Kewan
Published in: The application of clinical genetics (2020)
This study is the first to address the relationship between BRCA1 rs1799966 and rs799917 SNP, and the risk of GBM among the Arab Jordanian population. The findings of the study show that BRCA1 rs799917 is associated with decreased risk of GBM in the recessive model (AA vs G/G-A/G: OR, 0.46, 95% CI, 0.26-0.82, p=0.01) and the same SNP is associated with increased risk of GBM in the overdominant model (AG vs G/G-A/A: OR, 1.72, 95% CI, 1.02-2.89, p=0.04).
Keyphrases
  • dna repair
  • genome wide
  • dna damage
  • dna methylation
  • gene expression
  • autism spectrum disorder
  • high density
  • intellectual disability
  • dna damage response
  • duchenne muscular dystrophy
  • breast cancer risk