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Characterization of Prostacyclin-associated Leg Pain in Patients with Pulmonary Arterial Hypertension.

Gabriel L Pagani-EstévezKeith M SwetzMichael D McGoonRobert P FrantzSusan K TointonAnn M KarnyskiLouise A DurstJames C Watson
Published in: Annals of the American Thoracic Society (2018)
Chronic prostacyclin-associated leg pain is associated with a small-fiber neuropathy. Treatable metabolic contributors (vitamin B12 deficiency, thyroid dysfunction, or diabetes) appear to be common possible "second hits" that may be underrecognized. We recommend screening for possible metabolic contributors in patients who have otherwise unexplained leg pain in the setting of PAH and current or anticipated prostacyclin therapy.
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