Joint effect of testosterone and neurofilament light chain on cognitive decline in men: The Shanghai Aging Study.

Shuning TangZhenxu XiaoFangting LinXiaoniu LiangXiaoxi MaJie WuXiaowen ZhouQianhua ZhaoJunling GaoQianyi XiaoDing Ding

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Testosterone is inversely associated with cognitive decline in older men. There is a joint effect of testosterone and NfL on cognitive decline. Sex hormone and neurodegeneration may synergistically contribute to cognitive deterioration.

Keyphrases

cognitive decline
mild cognitive impairment
replacement therapy
middle aged
physical activity
smoking cessation
community dwelling