Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals, March-May 2020.

Sameer S KadriCumhur Y DemirkaleJunfeng SunLindsay M BuschJeffrey R StrichNing RosenthalSarah Warner

Published in: Open forum infectious diseases (2020)

We report off-label use patterns for medications repurposed for coronavirus disease 2019 (COVID-19) at 318 US hospitals. Inpatient hydroxychloroquine use declined by 80%, whereas corticosteroids and tocilizumab were initiated 2 days earlier in May versus March 2020. Two thirds of ventilated COVID-19 patients were already receiving corticosteroids during March-May 2020, resembling pre-COVID use in mechanically ventilated influenza patients.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
intensive care unit
end stage renal disease
healthcare
palliative care
ejection fraction
newly diagnosed
mental health
rheumatoid arthritis
prognostic factors
peritoneal dialysis
juvenile idiopathic arthritis
disease activity